منابع مشابه
Factors regulating microglia activation
Microglia are resident macrophages of the central nervous system (CNS) that display high functional similarities to other tissue macrophages. However, it is especially important to create and maintain an intact tissue homeostasis to support the neuronal cells, which are very sensitive even to minor changes in their environment. The transition from the "resting" but surveying microglial phenotyp...
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Selective elimination of synaptic connections is a common phenomenon which occurs during both developmental and pathological conditions. Glial cells have a central role in the pruning of synapses by specifically engulfing the degenerating neurites of inappropriate connections, but its regulatory mechanisms have been largely unknown. To identify mediators of this process, we established an in vi...
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Microglia are the immune cells in the central nervous system and control the brain homeostasis [1]. When microglia find either infected or dead cells in brain, they are activated and ingest debris to maintain the normal brain condition. Although microglia modulate brain environment via macrophage-like aspects, they also play important roles in the developing brain. In the past few years, severa...
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Synaptic plasticity is thought to be initiated by neurons only, with the prevailing view assigning glial cells mere specify supportive functions for synaptic transmission and plasticity. We now demonstrate that glial cells can control synaptic strength independent of neuronal activity. Here we show that selective activation of microglia in the rat is sufficient to rapidly facilitate synaptic st...
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1 CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal 2 PhD Programme in Experimental Biology and Biomedicine (PDBEB), Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal 3 Faculty of Medicine, Biochemistry, University of Coimbra, Coimbra, Portugal 4 Faculty of Medicine, Pharmacology and Experimental Therapeutics, University of C...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2013
ISSN: 1662-5102
DOI: 10.3389/fncel.2013.00044